Publisher description
The discovery of this family of proteins three decades ago launched a broad
range of research effort that now reaches across many potential applications in
human reproductive biology, inflammatory diseases, endocrinology, and in
oncology. These proceedings papers extend the new function research
possibilities inherent in the structure of this steroid-inducible,
multifunctional secreted protein, and in the UG-bioactive-derived peptides. An
opening overview of the UG family focuses on mammaglobin and its implications
with human breast cancer; the sequence/structure sections review applications
of antiflammin responses from its peptide. Other sections present new research
on regulation of uteroglobin genes by cytokines and hormones; and clinical
applications for renal diseases, in targeting gene therapy in pulmonary
disease. Together, these developments raise the possibility of
cytokine/chemokine-like functions that play important roles in major public
health problems. A consensus of nomenclature for Uteroglobin/Clara Cell 10kDa
family of proteins is also advanced as a step to coordinating new areas of
research for these promising proteins and receptors. These proceedings papers extend the new function research possibilities
inherent in the structure of this steroid-inducible, multifunctional secreted
protein, and in the UG-bioactive-derived peptides.
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Uteroglobin/Clara Cell Protein Family
Book reviews » Uteroglobin/Clara Cell Protein Family (Annals of the New York Academy of Sciences)
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