Publisher description
Despite its universality in human female ageing, the menopause and its
biology are not completely understood. New biologic mechanisms by which sex
hormones may be detrimental or confer protection are continually being
discovered. We are now starting to understand that the role of the oestrogen receptor
is not identical in all tissues. Important nongenomic effects for sex hormones
have also been described. Hormone replacement therapy (HRT) has produced
effects on health risks: some are reduced, some are increased, and the rest
remain uncertain. HRT is being used by an increasing number of women to
alleviate climacteric symptoms in the perimenopausal period and to prevent
osteoporosis and cardiovascular disease later. Positive effects on Alzheimer's
disease and dementia on the one hand, and an increase in venous thrombosis on
the other, are currently being reported by several groups. Both the preventive
benefits and the risk of breast cancer seem to be linked to long-term and
current use. HRT requires further testing through specific clinical trials,
currently underway in the United States, before confident recommendations may
be made about the full range of benefits and risks. Despite its universality in human female ageing, the menopause and its
biology are not completely understood. New biologic mechanisms by which sex
hormones may be detrimental or confer protection are continually being
discovered. This book discusses the extent of advance at the present time.
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Women's Health and Menopause: Risk Reduction Strategies
Book reviews » Women's Health and Menopause: Risk Reduction Strategies (Medical Science Symposia Series)
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